New awards, FY2015-2016

Major Funding

William Gillanders, MD

Division of General Surgery, Section of Endocrine and Oncologic Surgery
Department of Defense/U.S. Army; Phase 1B Clinical Trial of a Candidate Breast Cancer Prevention Vaccine. (W8/XWH-15-1-0101). 7/1/15-6/30/20

The grant focuses on development of a mammaglobin-A DNA vaccine. Mammaglobin-A is a protein that is overexpressed in almost all breast cancers and is an attractive target for breast cancer vaccine therapy. The vaccine will be tested in patients being treated with neoadjuvant endocrine therapy.

Siobhan Sutcliffe, PhD, ScM, MHS

Division of Public Health Sciences
NIH; LUTS Prevention in Adolescent Girls and Women Across the Lifespan (U01DK106853). 8/15/15-6/30/20

The PLUS Consortium will identify promising strategies for promoting bladder health and preventing lower urinary tract symptoms (LUTS) and conditions in women throughout the lifespan. Using multiple complementary research approaches, the consortium will obtain information to identify both protective factors and risk factors for LUTS. The focus will be on obtaining the necessary information to plan future educational efforts to promote bladder health and prevent LUTS.

Aimee James, PhD, MPH

Division of Public Health Sciences
NIH; Understanding and Addressing Cost-Related Nonadherence to Medication: a Mixed Method Multi-phase Study (R01MD010445). 4/1/06-11/30/18

This grant from the National Institute on Minority Health and Health Disparities will focus on helping low-income patients cope with high medical costs and low financial resources. James and co-investigators will develop a pilot intervention to reduce nonadherence related to cost. The overall goal is to help improve health outcomes and reduce health disparities.

Amy Moore, MD

Division of Plastic and Reconstructive Surgery
Department of Defense; Macroscopic Management of Neuromas in Residual Limbs (W81XWH-15-1-0625). 9/30/15-9/29/18

A major cause of residual limb pain in the amputee is the development of symptomatic neuromas. The grant will fund research to explore the ability to “reset” nerve regeneration in a proximal nerve after the nerve has been crushed and a neuroma removed. Researchers propose to inhibit neuroma formation with the use of a long processed nerve allograft attached to the nerve end, which they hypothesize will reduce neuroma regeneration over time.

Additional Funding

Cardiothoracic Surgery

Xingan Wang, MD, PhD

Section of General Thoracic Surgery
American Society of Hematology/The Role of Neutrophil Extracellular Traps on Lung Transplant Tolerance. 7/1/15-6/30/17

Andrew Gelman, PhD

Section of General Thoracic Surgery
Quark Pharmaceuticals/The Evaluation of Quark siRNA in Mouse Lung Transplants. 10/14/15-10/13/16

General Surgery

William Hawkins, MD

Section of Hepatobiliary-Pancreatic and Gastrointestinal Surgery
Fox Family Foundation and The Foundation for Barnes-Jewish Hospital/Phase I Study of Defactinib Combined with Pembrolizumab and Gemcitabine in Patients with Advanced Cancer. 1/1/16-12/31/17

William Gillanders, MD

Section of Endocrine and Oncologic Surgery
Siteman Cancer Center SIP Pre-SPORE/Siteman Cancer Center Breast Cancer SPORE. 1/1/16-12/31/16

Grant Bochicchio, MD, MPH

Section of Acute and Critical Care Surgery
Department of Defense – Neumedicines, Inc./A Phase IIa Open-Label, Randomized Study to Compare the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of NM-IL-12 (rHuIL-12) to Standard of Care in Subjects with Open Surgical Wounds Following Colostomy Takedown Allowed to Heal by Secondary Intention. 11/4/15-11/3/16

William Hawkins, MD

Section of Hepatobiliary-Pancreatic and Gastrointestinal Surgery
Precision Medicine Research Associates/ Development of a Therapeutic Agent for Pancreatic Cancer/PMRA20151218.1HAWKINS. 12/18/15-12/15/17

Grant Bochicchio, MD, MPH

Section of Acute and Critical Care Surgery
The Foundation for Barnes-Jewish Hospital/Wound Care Registry. 7/1/15-6/30/16

Ryan Fields, MD

Section of Hepatobiliary-Pancreatic and Gastrointestinal Surgery
The Foundation for Barnes-Jewish Hospital/ Improving Mental and Physical Health and Decreasing Hospital Readmission after Pancreatectomy Through Enhanced Patient and Caregiver Education and Engagement/8078-88. 10/1/15-9/30/17

Grant Bochicchio, MD, MPH

Section of Acute and Critical Care Surgery
$104,555 (paid per patient)
Subaward from University of Colorado (prime sponsor: National Institutes of Health)
Sigh Ventilation to Reduce the Incidence And/Or Severity Of The Acute Respiratory Distress Syndrome. 9/15/15-7/31/20

Public Health Sciences

Bettina Drake, MPH, PhD

DOD/Prostate Cancer Biospecimen Cohort Study. 9/30/15-9/29/18

Graham Colditz, MD, DrPH

NIH; 2/2 Addressing Rural Cancer Health Disparities: an SCC-SIUSM Partnership (P20CA192966). 9/9/15-8/31/18

Adetunji Toriola, MD, MPH, PhD

Susan G. Komen for the Cure/Receptor Activator of Nuclear Factor-kB (RANK)-Axis and Mammographic Density/CCR15332379. 10/1/15-9/30/18

Mary Politi, PhD

Agency for Healthcare Research and Quality (AHRQ)/A Conference Grant to Implement Comparative Effectiveness Research into Policy. 7/10/15-4/30/18

Graham Colditz, MD, DrPH

Siteman Cancer Center SIP Pre-R01/Premenopausal Plasma Carotenoids and Incident Premalignant Breast Diseases. 1/1/16-12/31/16

Urologic Surgery

Gerald Andriole, MD

NIH; Mechanisms of Bladder Urothelium-Nervous System Interactions in Health and Disease (U54DK104279). 9/25/15-8/31/16

An additional 16 awards were received totalling $306,663.